There are currently open positions for the completion of Master and Bachelor Theses. Please send a CV and a transcript to Pierre Stallforth.
Project 1: Isolation of amoebicidal secondary metabolites from soil bacteria
This project is centered on the isolation and structure elucidation of secondary metabolites with activity against bacterial predators. The student will use HPLC, LCMS, as well as spectroscopic techniques (NMR, HRMS) to isolate and elucidate the structure of bioactive secondary metabolites.
Project 2: Investigations towards the structure and function of amoebal polyketides
The aim of this project is to elucidate the function of polyketides in the social amoeba Dictyostelium discoideum . The main aspect is to apply genetic tools (generation of KO mutants and heterologous expression of biosynthetic genes) in order to understand the biological role of amoebal secondary metabolites.
A fully-funded PhD position is available:
Project: Cooperative effects in microbial interactions
We are interested in understanding the role of bacterially produced natural products (i.e. small molecular weight compounds such as antibiotics) in biological systems. While new antibiotics are urgently needed to combat life-threatening infectious diseases, not much is known why these compounds are produced in an ecological setting. We investigate scenarios in which bacteria use natural products to defend themselves against microbial predators (e.g. amoebae). In particular, we are interested in understanding cooperative defence mechanisms by which several bacteria jointly combat their predator. The PhD project will involve the isolation of bioactive natural products as well as studies towards the understanding of when and why these molecules are produced. This project combines research in the fields of biological chemistry, natural product biosynthesis, and chemical ecology.
please apply via the HKI application system:
Currently, there are no funded postdoc positions available. Candidates with their own funding are welcome to apply.